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In addition, the indole Main is substituted at R3 having a carbonyl group which can be also bonded to a napthalene moeity. Napthalene is usually a bicyclic composition of two fused benzene rings. This carbonyl bridge of JWH-018 classifies it to be a ketone. JWH-018 can be an analog of THJ-018, during which the Main indazole construction is substituted with an indole foundation. Pharmacology
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substituted naphthoyl derivatives in the naphthoylindole sequence, possessing a greater binding affinity at CB1
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